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Mechanisms of resistance to RAF inhibitors in melanoma

The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority patients. However, initial responses were followed by subsequent tumor...

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Autori principali: Aplin, Andrew E., Kaplan, Fred M., Shao, Yongping
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156870/
https://ncbi.nlm.nih.gov/pubmed/21593776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2011.147
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