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Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells
Melanoma cells are highly resistant to anoikis, a form of apoptosis induced in non-adherent/inappropriate adhesion conditions. Depleting B-RAF or the pro-survival Bcl-2 family protein Mcl-1 renders mutant B-RAF melanoma cells susceptible to anoikis. In this study, we examined the effect of targeting...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922482/ https://ncbi.nlm.nih.gov/pubmed/20647317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4471 |
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