Normal Human Pluripotent Stem Cell Lines Exhibit Pervasive Mosaic Aneuploidy

Human pluripotent stem cell (hPSC) lines have been considered to be homogeneously euploid. Here we report that normal hPSC – including induced pluripotent - lines are karyotypic mosaics of euploid cells intermixed with many cells showing non-clonal aneuploidies as identified by chromosome counting,...

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Auteurs principaux: Peterson, Suzanne E., Westra, Jurjen W., Rehen, Stevens K., Young, Holly, Bushman, Diane M., Paczkowski, Christine M., Yung, Yun C., Lynch, Candace L., Tran, Ha T., Nickey, Kyle S., Wang, Yu-Chieh, Laurent, Louise C., Loring, Jeanne F., Carpenter, Melissa K., Chun, Jerold
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156708/
https://ncbi.nlm.nih.gov/pubmed/21857983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023018
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