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Vitamin D Receptor Deficiency Enhances Wnt/β-Catenin Signaling and Tumor Burden in Colon Cancer

Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression of most colon cancers. This activation provokes the accumulation of nuclear β-catenin and the induction of its target genes. Apc(min/+) mice are the most commonly used model for colon cancer. They harbor...

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Dettagli Bibliografici
Autori principali: Larriba, María Jesús, Ordóñez-Morán, Paloma, Chicote, Irene, Martín-Fernández, Génesis, Puig, Isabel, Muñoz, Alberto, Pálmer, Héctor G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156234/
https://ncbi.nlm.nih.gov/pubmed/21858154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023524
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