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Mutation in the type IB bone morphogenetic protein receptor alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish

Germ-cell tumors (GCTs), which arise from pluripotent embryonic germ cells, exhibit a wide range of histologic differentiation states with varying clinical behaviors. Although testicular GCT is the most common cancer of young men, the genes controlling the development and differentiation of GCTs rem...

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Detalhes bibliográficos
Main Authors: Neumann, Joanie C., Chandler, Garvin L., Damoulis, Vanessa A., Fustino, Nicholas J., Lillard, Katherine, Looijenga, Leendert, Margraf, Linda, Rakheja, Dinesh, Amatruda, James F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156187/
https://ncbi.nlm.nih.gov/pubmed/21775673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102311108
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