Activation function 2 (AF2) of estrogen receptor-α is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

17β-Estradiol (E2) regulates estrogen receptor-α (ERα) target gene transcription through the two independent activation functions (AFs), AF1 and AF2, located in the N-terminal and ligand binding domain of ERα, respectively. We previously reported that ERα is required for the E2 atheroprotective acti...

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Autori principali: Billon-Galés, Audrey, Krust, Andrée, Fontaine, Coralie, Abot, Anne, Flouriot, Gilles, Toutain, Céline, Berges, Hortense, Gadeau, Alain-Pierre, Lenfant, Françoise, Gourdy, Pierre, Chambon, Pierre, Arnal, Jean-François
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156151/
https://ncbi.nlm.nih.gov/pubmed/21788522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105632108
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