The AF-1 activation-function of ERα may be dispensable to mediate the effect of estradiol on endothelial NO production in mice

Two isoforms of estrogen receptor (ER) have been described: ERα and ERβ. The initial gene targeting of ERα, consisting in the introduction of a Neo cassette in exon 1 [αERKO, hereafter called ERα-Neo KO (knockout)], was reported in 1993. More recently, another mouse deficient in ERα because of the d...

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Autores principales: Pendaries, C., Darblade, B., Rochaix, P., Krust, A., Chambon, P., Korach, K. S., Bayard, F., Arnal, J.-F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC122343/
https://ncbi.nlm.nih.gov/pubmed/11854517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.042688499
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