Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains largely unknown. Here, stemness factor mediated nuclear reprogramming reverted mitochondrial networks into cristae-poor structures. Metabolomic footprinting and fingerprinting distinguished derived pluripotent...

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Detalhes bibliográficos
Main Authors: Folmes, Clifford D. L., Nelson, Timothy J., Martinez-Fernandez, Almudena, Arrell, D. Kent, Lindor, Jelena Zlatkovic, Dzeja, Petras P., Ikeda, Yasuhiro, Perez-Terzic, Carmen, Terzic, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156138/
https://ncbi.nlm.nih.gov/pubmed/21803296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.06.011
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