Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo

Human telomerase, the reverse transcriptase which extends the life span of a cell by adding telomeric repeats to chromosome ends, is expressed in most cancer cells but not in the majority of normal somatic cells. Inhibition of telomerase therefore holds great promise as anticancer therapy. We have s...

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Hlavní autoři: Shammas, MA, Koley, H, Bertheau, RC, Neri, P, Fulciniti, M, Tassone, P, Blotta, S, Protopopov, A, Mitsiades, C, Batchu, RB, Anderson, KC, Chin, A, Gryaznov, S, Munshi, NC
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155939/
https://ncbi.nlm.nih.gov/pubmed/18449204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2008.81
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