Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

BACKGROUND: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death...

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Main Authors: Shammas, Masood A, Koley, Hemanta, Batchu, Ramesh B, Bertheau, Robert C, Protopopov, Alexei, Munshi, Nikhil C, Goyal, Raj K
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187920/
https://ncbi.nlm.nih.gov/pubmed/16022731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-24
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