Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

BACKGROUND: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death...

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Bibliografske podrobnosti
Main Authors: Shammas, Masood A, Koley, Hemanta, Batchu, Ramesh B, Bertheau, Robert C, Protopopov, Alexei, Munshi, Nikhil C, Goyal, Raj K
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2005
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187920/
https://ncbi.nlm.nih.gov/pubmed/16022731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-24
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