Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

BACKGROUND: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shammas, Masood A, Koley, Hemanta, Batchu, Ramesh B, Bertheau, Robert C, Protopopov, Alexei, Munshi, Nikhil C, Goyal, Raj K
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2005
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187920/
https://ncbi.nlm.nih.gov/pubmed/16022731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-24
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