Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

BACKGROUND: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death...

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Detalhes bibliográficos
Main Authors: Shammas, Masood A, Koley, Hemanta, Batchu, Ramesh B, Bertheau, Robert C, Protopopov, Alexei, Munshi, Nikhil C, Goyal, Raj K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187920/
https://ncbi.nlm.nih.gov/pubmed/16022731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-24
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