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Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach
Nearly all DNA polymerases require processivity factors to ensure continuous incorporation of nucleotides. Processivity factors are specific for their cognate DNA polymerases. For this reason, the vaccinia DNA polymerase (E9) and the proteins associated with processivity (A20 and D4) are excellent t...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155815/ https://ncbi.nlm.nih.gov/pubmed/18621425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.05.010 |
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