Selective p38α MAPK deletion in serotonergic neurons produces stress-resilience in models of depression and addiction

Maladaptive responses to stress adversely affect human behavior, yet the signaling mechanisms underlying stress-responsive behaviors remain poorly understood. Using a conditional gene knockout approach, the α isoform of p38 Mitogen Activated Protein Kinase (MAPK) was selectively inactivated by AAV1-...

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Detalhes bibliográficos
Main Authors: Bruchas, Michael R., Schindler, Abigail G., Shankar, Haripriya, Messinger, Daniel I., Miyatake, Mayumi, Land, Benjamin B., Lemos, Julia C., Hagan, Catherine, Neumaier, John F., Quintana, Albert, Palmiter, Richard D., Chavkin, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155685/
https://ncbi.nlm.nih.gov/pubmed/21835346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.06.011
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