Onset of Quiescence Following p53 Mediated Down-Regulation of H2AX in Normal Cells

Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability, although the mechanisms by which this is regulated are unclear. Here, we show that a growth-arrested cellular status is produced by...

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Main Authors: Atsumi, Yuko, Fujimori, Hiroaki, Fukuda, Hirokazu, Inase, Aki, Shinohe, Keitaro, Yoshioka, Yoshiko, Shikanai, Mima, Ichijima, Yosuke, Unno, Junya, Mizutani, Shuki, Tsuchiya, Naoto, Hippo, Yoshitaka, Nakagama, Hitoshi, Masutani, Mitsuko, Teraoka, Hirobumi, Yoshioka, Ken-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155552/
https://ncbi.nlm.nih.gov/pubmed/21858116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023432
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