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N−Heterocyclic Carbene and Brønsted Acid Cooperative Catalysis: Asymmetric Synthesis of trans−γ−Lactams
An efficient enantioselective approach to form trans-γ-lactams in up to 99% yield, 93% ee and >20/1 dr using unactivated imines has been developed. The cyclohexyl-substituted azolium and the weak base sodium o-chlorobenzoate are most suitable for this transformation. Notably, the process involves...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155423/ https://ncbi.nlm.nih.gov/pubmed/21780842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205714g |
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