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Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells
Small molecule inhibitors of Kinesin-5 (K5Is) that arrest cells in mitosis with monopolar spindles are promising anti-cancer drug candidates. Clinical trials of K5Is revealed dose-limiting neutropenia, or loss of neutrophils, for which the molecular mechanism is unclear. We investigated the effects...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155259/ https://ncbi.nlm.nih.gov/pubmed/21782324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.05.024 |
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