Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes

Sphingosine 1-phosphate (S1P), a pleiotropic lipid mediator, binds to five related G-protein-coupled receptors to exert its effects. As S1P1 receptor (S1P1R) activation blocks kidney inflammation in acute renal injury, we tested whether activation of S1P1Rs ameliorates renal injury in early-stage di...

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Bibliografski detalji
Glavni autori: Awad, Alaa S., Rouse, Michael D., Khutsishvili, Konstantine, Huang, Liping, Bolton, W. Kline, Lynch, Kevin R., Okusa, Mark D.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155206/
https://ncbi.nlm.nih.gov/pubmed/21289599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.544
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