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Total Synthesis of (±)-Cortistatin J from Furan

A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2-enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cy...

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Detalhes bibliográficos
Main Authors: Nilson, Mark G., Funk, Raymond L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154988/
https://ncbi.nlm.nih.gov/pubmed/21761900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja206138d
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