Production of α1,3-Galactosyltransferase–Deficient Pigs

The enzyme α1,3-galactosyltransferase (α1,3GT or GCTA1) synthesizes α1,3-galactose (α1,3Gal) epitopes (Galα1,3Galβ1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation. Complete removal of α1,3Gal from pig organs is the critical step toward t...

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Detalhes bibliográficos
Main Authors: Phelps, Carol J., Koike, Chihiro, Vaught, Todd D., Boone, Jeremy, Wells, Kevin D., Chen, Shu-Hung, Ball, Suyapa, Specht, Susan M., Polejaeva, Irina A., Monahan, Jeff A., Jobst, Pete M., Sharma, Sugandha B., Lamborn, Ashley E., Garst, Amy S., Moore, Marilyn, Demetris, Anthony J., Rudert, William A., Bottino, Rita, Bertera, Suzanne, Trucco, Massimo, Starzl, Thomas E., Dai, Yifan, Ayares, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154759/
https://ncbi.nlm.nih.gov/pubmed/12493821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1078942
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