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Eosinophils generate brominating oxidants in allergen-induced asthma

Eosinophils promote tissue injury and contribute to the pathogenesis of allergen-triggered diseases like asthma, but the chemical basis of damage to eosinophil targets is unknown. We now demonstrate that eosinophil activation in vivo results in oxidative damage of proteins through bromination of tyr...

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Pubblicato in:J Clin Invest
Autori principali: Wu, Weijia, Samoszuk, Michael K., Comhair, Suzy A.A., Thomassen, Mary Jane, Farver, Carol F., Dweik, Raed A., Kavuru, Mani S., Erzurum, Serpil C., Hazen, Stanley L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
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Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC315470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811853/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9702
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