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Effect of the α2δ ligand, pregabalin, on colonic sensory and motor functions in healthy adults

Pregabalin, an α2δ ligand, is used clinically to treat somatic pain. A prior study suggested that pregabalin reduces distension-induced pain while increasing rectal compliance. We aimed to quantify effects of pregabalin on colonic sensory and motor functions and assess relationships between sensory...

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Autori principali: Iturrino, Johanna, Camilleri, Michael, Busciglio, Irene, Burton, Duane, Zinsmeister, Alan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154609/
https://ncbi.nlm.nih.gov/pubmed/21596994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00085.2011
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