Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects

Lubiprostone, a bicyclic fatty acid chloride channel activator, is efficacious in treatment of chronic constipation and constipation-predominant irritable bowel syndrome. The study aim was to compare effects of lubiprostone and placebo on colonic sensory and motor functions in humans. In double-blin...

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Detalhes bibliográficos
Main Authors: Sweetser, Seth, Busciglio, Irene A., Camilleri, Michael, Bharucha, Adil E., Szarka, Lawrence A., Papathanasopoulos, Athanasios, Burton, Duane D., Eckert, Deborah J., Zinsmeister, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643920/
https://ncbi.nlm.nih.gov/pubmed/19033530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90558.2008
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