Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase

Statins are 3-hydroxyl-3-methyglutaryl-CoA reductase inhibitors that are commonly used to inhibit cholesterol biosynthesis. Emerging data have suggested that they also have “pleotropic effects,” including modulating actin cytoskeleton reorganization. Here, we report an effect of simvastatin on the t...

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Autores principales: Li, Wei, Zhang, Yan, Bouley, Richard, Chen, Ying, Matsuzaki, Toshiyuki, Nunes, Paula, Hasler, Udo, Brown, Dennis, Lu, Hua A. Jenny
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154588/
https://ncbi.nlm.nih.gov/pubmed/21511701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00001.2011
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