Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase

Statins are 3-hydroxyl-3-methyglutaryl-CoA reductase inhibitors that are commonly used to inhibit cholesterol biosynthesis. Emerging data have suggested that they also have “pleotropic effects,” including modulating actin cytoskeleton reorganization. Here, we report an effect of simvastatin on the t...

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Detalhes bibliográficos
Main Authors: Li, Wei, Zhang, Yan, Bouley, Richard, Chen, Ying, Matsuzaki, Toshiyuki, Nunes, Paula, Hasler, Udo, Brown, Dennis, Lu, Hua A. Jenny
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154588/
https://ncbi.nlm.nih.gov/pubmed/21511701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00001.2011
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