Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Endothelin-converting enzyme-1 and -2 (ECE-1 and -2) are membrane-bound metalloproteases that can cleave biologically the inactive endothelin-1 (ET-1) precursor to form active ET-1 in vitro. We previously reported developmental defects in specific subsets of neural crest–derived tissues, including b...

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Bibliographic Details
Main Authors: Yanagisawa, Hiromi, Hammer, Robert E., Richardson, James A., Emoto, Noriaki, Williams, S. Clay, Takeda, Shin-ichi, Clouthier, David E., Yanagisawa, Masashi
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC315458/
https://ncbi.nlm.nih.gov/pubmed/10811845
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