Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

Withaferin A (WA), a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera, inhibits growth of MDA-MB-231 and MCF-7 human breast cancer cells in culture and MDA-MB-231 xenografts in vivo in association with apoptosis induction, but the mechanism of cell death is not fully...

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Main Authors: Hahm, Eun-Ryeong, Moura, Michelle B., Kelley, Eric E., Van Houten, Bennett, Shiva, Sruti, Singh, Shivendra V.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154436/
https://ncbi.nlm.nih.gov/pubmed/21853114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023354
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