Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets
STAT4 and STAT6 are transcription factors that play crucial roles in responding to IL-12 and IL-4, respectively. STAT4 gene knockout (STAT4(–/–)) mice have markedly reduced Th1 responses and enhanced Th2 responses. STAT6(–/–) mice show the inverse phenotype. We compared the ability of bone marrow tr...
Gespeichert in:
| Veröffentlicht in: | J Clin Invest |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2000
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC315439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10792004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7894 |
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