Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets

STAT4 and STAT6 are transcription factors that play crucial roles in responding to IL-12 and IL-4, respectively. STAT4 gene knockout (STAT4(–/–)) mice have markedly reduced Th1 responses and enhanced Th2 responses. STAT6(–/–) mice show the inverse phenotype. We compared the ability of bone marrow tr...

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Bibliografske podrobnosti

izdano v:	J Clin Invest
Principais autores:	Nikolic, Boris, Lee, Seika, Bronson, Roderick T., Grusby, Michael J., Sykes, Megan
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 2000
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC315439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10792004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7894
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