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Epidermal growth factor receptor expression in neurofibromatosis type 1–related tumors and NF1 animal models

We have found that EGF-R expression is associated with the development of the Schwann cell–derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack EGF-R and respond to ligands other than EGF. Nevert...

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Detalhes bibliográficos
Main Authors: DeClue, Jeffrey E., Heffelfinger, Sue, Benvenuto, Giovanna, Ling, Bo, Li, Shaowei, Rui, Wen, Vass, William C., Viskochil, David, Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC315438/
https://ncbi.nlm.nih.gov/pubmed/10791998
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