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The Effect of the Potential PhoQ Histidine Kinase Inhibitors on Shigella flexneri Virulence
PhoQ/PhoP is an important two-component system that regulates Shigella virulence. We explored whether the PhoQ/PhoP system is a promising target for new antibiotics against S. flexneri infection. By using a high-throughput screen and enzymatic activity coupled assay, four compounds were found as pot...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3154276/ https://ncbi.nlm.nih.gov/pubmed/21853073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023100 |
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