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Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension

Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPs). Here we report that RPTPs act...

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Detalhes bibliográficos
Main Authors: Coles, Charlotte H., Shen, Yingjie, Tenney, Alan P., Siebold, Christian, Sutton, Geoffrey C., Lu, Weixian, Gallagher, John T., Jones, E. Yvonne, Flanagan, John G., Aricescu, A. Radu
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154093/
https://ncbi.nlm.nih.gov/pubmed/21454754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1200840
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