Local Low-Dose Lovastatin Delivery Improves the Bone-Healing Defect Caused by Nf1 Loss of Function in Osteoblasts

Postfracture tibial nonunion (pseudoarthrosis) leads to lifelong disability in patients with neurofibromatosis type I (NF1), a disorder caused by mutations in the NF1 gene. To determine the contribution of NF1 in bone healing, we assessed bone healing in the [Image: see text] conditional mouse model...

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Main Authors: Wang, Weixi, Nyman, Jeffry S, Moss, Heather E, Gutierrez, Gloria, Mundy, Gregory R, Yang, Xiangli, Elefteriou, Florent
格式: Artigo
語言:Inglês
出版: Wiley Subscription Services, Inc., A Wiley Company 2010
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154004/
https://ncbi.nlm.nih.gov/pubmed/20200958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.42
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