Contribution of the basolateral isoform of the Na,K,2Cl-cotransporter (NKCC1/BSC2) to renin secretion

Acute administration of loop diuretics like furosemide leads to a stimulation of renin secretion, an effect thought to result from inhibition of NKCC2-mediated salt transport at the luminal surface of the macula densa (MD). However, loop diuretics also inhibit NKCC1, the second isoform of the Na/K/2...

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Detalhes bibliográficos
Main Authors: Castrop, Hayo, Lorenz, John N., Hansen, Pernille, Friis, Ulla, Mizel, Diane, Oppermann, Mona, Jensen, Boye, Briggs, Josie, Skott, Ole, Schnermann, Jurgen
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153878/
https://ncbi.nlm.nih.gov/pubmed/16106034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00455.2004
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