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Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics
We report a new acid-sensitive, biocompatible and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3152952/ https://ncbi.nlm.nih.gov/pubmed/21539393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100542r |
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