Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics

We report a new acid-sensitive, biocompatible and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cohen, Jessica L., Schubert, Stephanie, Wich, Peter R., Cui, Lina, Cohen, Joel A., Mynar, Justin L., Fréchet, Jean M. J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152952/
https://ncbi.nlm.nih.gov/pubmed/21539393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100542r
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