Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy

Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER stress, but...

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Autors principals: Caviglia, Jorge Matias, Gayet, Constance, Ota, Tsuguhito, Hernandez-Ono, Antonio, Conlon, Donna M., Jiang, Hongfeng, Fisher, Edward A., Ginsberg, Henry N.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2011
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151684/
https://ncbi.nlm.nih.gov/pubmed/21719579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M016931
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