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Neutrophils Activate Alveolar Macrophages by producing Caspase-6 Mediated Cleavage of Interleukin-1 Associated Kinase-M (IRAK-M)

Alveolar macrophages (AM) are exposed to respirable microbial particles. Similar to phagocytes in the gastrointestinal tract, AM can suppress inflammation after exposure to nonpathogenic organisms. IRAK-M is one inhibitor of innate immunity, normally suppressing pulmonary inflammation. During pneumo...

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Detalhes bibliográficos
Main Authors: Kobayashi, Hiroshi, Nolan, Anna, Naveed, Bushra, Hoshino, Yoshihiko, Segal, Leopoldo N., Fujita, Yoko, Rom, William N., Weiden, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151149/
https://ncbi.nlm.nih.gov/pubmed/21098228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001906
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