Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

Mycolactone is a macrolide produced by Mycobacterium ulcerans with immunomodulatory properties. Here, we describe that in mouse, mycolactone injection led to a massive T-cell depletion in peripheral lymph nodes (PLNs) that was associated with defective expression of L-selectin (CD62-L). Importantly,...

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Autors principals: Guenin-Macé, Laure, Carrette, Florent, Asperti-Boursin, François, Le Bon, Agnès, Caleechurn, Laxmee, Di Bartolo, Vincenzo, Fontanet, Arnaud, Bismuth, Georges, Demangel, Caroline
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150933/
https://ncbi.nlm.nih.gov/pubmed/21768364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016496108
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