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The naïve airway hyperresponsiveness of the A/J mouse is Kit-mediated

There is a wide variation among humans and mice in airway hyperresponsiveness (AHR) in the absence of allergen sensitization, i.e., naïve AHR. Because mast cell (MC) activation is thought to mediate AHR in atopic asthmatic subjects, we asked whether MCs mediate naïve AHR in A/J mice. We generated an...

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Detalhes bibliográficos
Main Authors: Cozzi, Emily, Ackerman, Kate G., Lundequist, Anders, Drazen, Jeffrey M., Boyce, Joshua A., Beier, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150901/
https://ncbi.nlm.nih.gov/pubmed/21768379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106582108
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