Myosin Cross-Bridges Do Not Form Precise Rigor Bonds in Hypertrophic Heart Muscle Carrying Troponin T Mutations

Distribution of orientations of myosin was examined in ex-vivo myofibrils from hearts of transgenic (Tg) mice expressing Familial Hypertrophic Cardiomyopathy (FHC) troponin T (TnT) mutations I79N, F110I and R278C. Humans are heterozygous for sarcomeric FHC mutations and so hypertrophic myocardium co...

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Detalhes bibliográficos
Main Authors: Midde, K., Dumka, V., Pinto, J.R., Muthu, P., Marandos, P., Gryczynski, I., Gryczynski, Z., Potter, J.D., Borejdo, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150405/
https://ncbi.nlm.nih.gov/pubmed/21683708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.06.001
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