Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α (HIF-1α) in Advanced Solid Tumors

PURPOSE: Hypoxia-inducible factor 1 (HIF-1) α is frequently overexpressed in human tumors and is associated with angiogenesis and metastasis. Topotecan, a topoisomerase I inhibitor, has been shown to inhibit HIF-1α expression in preclinical models. We designed a pilot trial to measure HIF-1α inhibit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kummar, Shivaani, Raffeld, Mark, Juwara, Lamin, Horneffer, Yvonne, Strassberger, Agnes, Allen, Deborah, Steinberg, Seth M., Rapisarda, Annamaria, Spencer, Shawn D., Figg, William D., Chen, Xiaohong, Turkbey, Ismail Baris, Choyke, Peter, Murgo, Anthony J., Doroshow, James H., Melillo, Giovanni
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149769/
https://ncbi.nlm.nih.gov/pubmed/21673063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0682
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