Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α (HIF-1α) in Advanced Solid Tumors

PURPOSE: Hypoxia-inducible factor 1 (HIF-1) α is frequently overexpressed in human tumors and is associated with angiogenesis and metastasis. Topotecan, a topoisomerase I inhibitor, has been shown to inhibit HIF-1α expression in preclinical models. We designed a pilot trial to measure HIF-1α inhibit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kummar, Shivaani, Raffeld, Mark, Juwara, Lamin, Horneffer, Yvonne, Strassberger, Agnes, Allen, Deborah, Steinberg, Seth M., Rapisarda, Annamaria, Spencer, Shawn D., Figg, William D., Chen, Xiaohong, Turkbey, Ismail Baris, Choyke, Peter, Murgo, Anthony J., Doroshow, James H., Melillo, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149769/
https://ncbi.nlm.nih.gov/pubmed/21673063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0682
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados