Enhancement of 5- Fluorouracil-induced In Vitro and In Vivo Radiosensitization with MEK Inhibition

PURPOSE: Gastrointestinal cancers frequently exhibit mutational activation of the Ras/MAPK pathway, which is implicated in resistance to ionizing radiation (IR) and chemotherapy. Concurrent radiotherapy and 5-fluorouracil (5-FU) based chemotherapy is commonly used for treatment of gastrointestinal m...

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Bibliografiske detaljer
Main Authors: Urick, Mary Ellen, Chung, Eun Joo, Shield, William P., Gerber, Naamit, White, Ayla, Sowers, Anastasia, Thetford, Angela, Camphausen, Kevin, Mitchell, James, Citrin, Deborah E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149743/
https://ncbi.nlm.nih.gov/pubmed/21690569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0358
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