Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional repression. Next-generation sequencing of purified methylated DNA obtained from early Xenopus tropicalis embryos demonstrates that this genome is heavily methylated during blastula and gastrula stages. Although DN...

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Detalhes bibliográficos
Principais autores: Bogdanović, Ozren, Long, Steven W., van Heeringen, Simon J., Brinkman, Arie B., Gómez-Skarmeta, Jose Luis, Stunnenberg, Hendrik G., Jones, Peter L., Veenstra, Gert Jan C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149498/
https://ncbi.nlm.nih.gov/pubmed/21636662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.114843.110
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