Pheromone- and RSP5-dependent Ubiquitination of the G Protein β Subunit Ste4 in Yeast

Ste4 is the β subunit of a heterotrimeric G protein that mediates mating responses in Saccharomyces cerevisiae. Here we show that Ste4 undergoes ubiquitination in response to pheromone stimulation. Ubiquitination of Ste4 is dependent on the E3 ligase Rsp5. Disrupting the activity of Rsp5 abolishes u...

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Bibliographic Details
Main Authors: Zhu, Ming, Torres, Matthew P., Kelley, Joshua B., Dohlman, Henrik G., Wang, Yuqi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149308/
https://ncbi.nlm.nih.gov/pubmed/21685393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254193
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