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Pheromone- and RSP5-dependent Ubiquitination of the G Protein β Subunit Ste4 in Yeast
Ste4 is the β subunit of a heterotrimeric G protein that mediates mating responses in Saccharomyces cerevisiae. Here we show that Ste4 undergoes ubiquitination in response to pheromone stimulation. Ubiquitination of Ste4 is dependent on the E3 ligase Rsp5. Disrupting the activity of Rsp5 abolishes u...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149308/ https://ncbi.nlm.nih.gov/pubmed/21685393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254193 |
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