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Homologous Elements hs3a and hs3b in the 3′ Regulatory Region of the Murine Immunoglobulin Heavy Chain (Igh) Locus Are Both Dispensable for Class-switch Recombination

Immunoglobulin heavy chain (IgH) genes are formed, tested, and modified to yield diverse, specific, and high affinity antibody responses to antigen. The processes involved must be regulated, however, to avoid unintended damage to chromosomes. The 3′ regulatory region of the Igh locus plays a major r...

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Detalles Bibliográficos
Main Authors: Yan, Yi, Pieretti, Joyce, Ju, Zhongliang, Wei, Shiniu, Christin, John R., Bah, Fatmata, Birshtein, Barbara K., Eckhardt, Laurel A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149305/
https://ncbi.nlm.nih.gov/pubmed/21673112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230995
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