Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and p90(RSK) in the Control of mTORC1 Protein Signaling by Phorbol Esters

The mammalian target of rapamycin complex 1 (mTORC1) links the control of mRNA translation, cell growth, and metabolism to diverse stimuli. Inappropriate activation of mTORC1 can lead to cancer. Phorbol esters are naturally occurring products that act as potent tumor promoters. They activate isoform...

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Autors principals: Fonseca, Bruno D., Alain, Tommy, Finestone, Leona K., Huang, Brandon P. H., Rolfe, Mark, Jiang, Tian, Yao, Zhong, Hernandez, Greco, Bennett, Christopher F., Proud, Christopher G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149304/
https://ncbi.nlm.nih.gov/pubmed/21659537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260794
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