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Characterization of Oligomer Formation of Amyloid-β Peptide Using a Split-luciferase Complementation Assay

Amyloid-β peptide (Aβ) is the amyloid component of senile plaques in Alzheimer disease (AD) brains. Recently a soluble oliomeric form of Aβ in Aβ precursor protein transgenic mouse brains and AD brains was identified as a potential causative molecule for memory impairment, suggesting that soluble Aβ...

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Autors principals: Hashimoto, Tadafumi, Adams, Kenneth W., Fan, Zhanyun, McLean, Pamela J., Hyman, Bradley T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149301/
https://ncbi.nlm.nih.gov/pubmed/21652708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257378
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