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How Robust Are Protein Folding Simulations with Respect to Force Field Parameterization?

Molecular dynamics simulations hold the promise of providing an atomic-level description of protein folding that cannot easily be obtained from experiments. Here, we examine the extent to which the molecular mechanics force field used in such simulations might influence the observed folding pathways...

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Bibliografische gegevens
Hoofdauteurs: Piana, Stefano, Lindorff-Larsen, Kresten, Shaw, David E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149239/
https://ncbi.nlm.nih.gov/pubmed/21539772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.03.051
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