Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus

Diazepam (DZP) and phenobarbital (PB) are extensively used as first and second line drugs to treat acute seizures in neonates and their actions are thought to be mediated by increasing the actions of GABAergic signals. Yet, their efficacy is variable with occasional failure or even aggravation of re...

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Main Authors: Nardou, Romain, Yamamoto, Sumii, Bhar, Asma, Burnashev, Nail, Ben-Ari, Yehezkel, Khalilov, Ilgam
格式: Artigo
語言:Inglês
出版: Frontiers Research Foundation 2011
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148783/
https://ncbi.nlm.nih.gov/pubmed/21847371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2011.00016
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