Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor–dependent pathway

Hypertension is a leading contributor to cardiovascular mortality worldwide. Despite this, its underlying mechanism(s) and the role of excess salt in cardiorenal dysfunction are unclear. Previously, we have identified cross-talk between mineralocorticoid receptor (MR), a nuclear transcription factor...

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Main Authors: Shibata, Shigeru, Mu, ShengYu, Kawarazaki, Hiroo, Muraoka, Kazuhiko, Ishizawa, Ken-ichi, Yoshida, Shigetaka, Kawarazaki, Wakako, Takeuchi, Maki, Ayuzawa, Nobuhiro, Miyoshi, Jun, Takai, Yoshimi, Ishikawa, Akira, Shimosawa, Tatsuo, Ando, Katsuyuki, Nagase, Miki, Fujita, Toshiro
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148723/
https://ncbi.nlm.nih.gov/pubmed/21765214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43124
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