Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

Type 1 diabetes is characterized by destruction of insulin-producing β cells in the pancreatic islets by effector T cells. Tregs, defined by the markers CD4 and FoxP3, regulate immune responses by suppressing effector T cells and are recruited to sites of action by the chemokine CCL22. Here, we demo...

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Main Authors: Montane, Joel, Bischoff, Loraine, Soukhatcheva, Galina, Dai, Derek L., Hardenberg, Gijs, Levings, Megan K., Orban, Paul C., Kieffer, Timothy J., Tan, Rusung, Verchere, C. Bruce
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148722/
https://ncbi.nlm.nih.gov/pubmed/21737880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43048
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