CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR) chloride channels causes defective secretion by submucosal glands (SMGs), leading to persistent bacterial infection that damages airways and necessitates tissue repair. SMGs are also important niches for slow...

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Main Authors: Xie, Weiliang, Fisher, John T., Lynch, Thomas J., Luo, Meihui, Evans, Turan I.A., Neff, Traci L., Zhou, Weihong, Zhang, Yulong, Ou, Yi, Bunnett, Nigel W., Russo, Andrew F., Goodheart, Michael J., Parekh, Kalpaj R., Liu, Xiaoming, Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148720/
https://ncbi.nlm.nih.gov/pubmed/21765217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41857
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