CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR) chloride channels causes defective secretion by submucosal glands (SMGs), leading to persistent bacterial infection that damages airways and necessitates tissue repair. SMGs are also important niches for slow...

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Detalhes bibliográficos
Main Authors: Xie, Weiliang, Fisher, John T., Lynch, Thomas J., Luo, Meihui, Evans, Turan I.A., Neff, Traci L., Zhou, Weihong, Zhang, Yulong, Ou, Yi, Bunnett, Nigel W., Russo, Andrew F., Goodheart, Michael J., Parekh, Kalpaj R., Liu, Xiaoming, Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148720/
https://ncbi.nlm.nih.gov/pubmed/21765217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41857
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